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The benefits were confirmed in an analysis that combined 23 separate randomized controlled trials together, where collagen peptides were shown to improve skin hydration and elasticity [27]
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Ongoing medication management

Both peptides have strong individual safety profiles, their mechanisms don't conflict, and clinical experience with the combination hasn't revealed unexpected adverse effects

Specifically, CD4 T cells show lower efficacy in recognizing EBV-transformed B cell lines that expressed HLA-DR15 (121, 122)
