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PMID: 17308274

First of all, the assessment of treatment efficacy in these studies are limited to the a reduction of senescent cell count as indicated by single markers such as p16 and SA--gal which, as mentioned earlier in this review, may not be an accurate representation of the exact populations targeted by the senolytic CAR-T

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Common pitfalls in 483 responses that lead to warning letters include: Superficial root cause analysis: Addressing only the immediate symptom of a problem without identifying the true underlying cause