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[15] Therefore, high doses of biotin (in the tens or hundreds of milligrams) are generally reserved for research settings or specific medical conditions like certain metabolic disorders or experimental therapies (e.g., very high-dose biotin has been investigated in multiple sclerosis)

Moreover, elderly people are also at higher risk as the ability to absorb vitamin B12 naturally declines with age

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With this in mind, it is important to consider the potential side effects of PPIs and assess the costs and benefits of long-term PPI use