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Diet and Nutritional Advice: Patients should also be advised to maintain a balanced diet to prevent future deficiencies, emphasizing foods high in thiamine such as whole grains, nuts, and legumes, alongside B-complex vitamins if necessary, to support overall health
Mechanisms that inhibit propagation of the DNA damage signal to the apoptotic machinery include loss of damage recognition, overexpression of HER-2/neu, activation of the PI3-K/Akt (also known as PI3-K/PKB) pathway, loss of p53 function, overexpression of antiapoptotic bcl-2, and interference in caspase activation
