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Arregui, Paulina Sury, Elena Quintana, Laura M
Cytosine residues in CpG dinucleotides can be modified through methylation (addition of CH3) by the enzyme methyltransferase [24]
Specifically, it increases the pro-apoptotic protein (Bax, Bim, Bad and Bak) expression, while decreasing anti-apoptotic protein (Bcl-2 and Bcl-xL) expression, and activates Poly (ADP-ribose) polymerase 1 (PARP1) and Caspase-3, ultimately triggering cell death [143]
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