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The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA

Prior to this action, ebselen needs to be reduced, i.e., the Se-containing ring is opened, and the Se is converted to selenol (-SeH)

Proc Natl Acad Sci U S A 91(8):31473150 Zhang J, Svehlikova V, Bao Y, Howie AF, Beckett GJ, Williamson G (2003) Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation
10.1136/ard.2009.120204 [DOI] [PubMed] [Google Scholar] Heimpel H., Anselstetter V., Chrobak L., Denecke J., Einsiedler B., Gallmeier K., et al
Pennsylvania Student Sustainability Symposium Location: Dickinson College Christine Josephine Burns Vertical forest structure, the diet of white-tailed deer, and their role as agents of seed dispersal Date: March 21, 2014 Event: 2014 Pennsylvania Environmental Resource Consortium
