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It serves as a crucial component of more than 300 enzymes and numerous functional proteins, participating in fundamental metabolic activities (e.g., DNA, RNA, protein, lipid, and vitamin metabolism) [3]

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PLoS ONE 10:e126599 Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor nrf2 through inactivation of keap1

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