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The metabolic effects that promote glucose uptake acutely can, with chronic exposure, lead to cells becoming less responsive to insulin's signals

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While insights from oncology provide valuable clues for understanding ferroptosis regulation in AD, the distinct pathological microenvironment of ADcharacterized by A deposition, tau pathology, and chronic neuroinflammationsuggests that these epigenetic regulatory mechanisms likely exhibit disease-specific features

In SZ patients, the abundance of SCFA-producing bacteria is often altered, leading to reduced SCFA levels, which weakens the capacity to suppress inflammation