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The classical mechanism of antifolate drugs involves disruption of 1C metabolism, whereas SHMT inhibitors primarily function by limiting glycine synthesis
Groups of BALB/c mice were challenged intranasally with 110 7 CFU of the wt, gpoA , and wt gpoA + strains individually
Puri, Uday Bandyopadhyay Free Radical Biology and Medicine .2008
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