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It promotes neurogenesis and enhances the action of neurotrophic factors. An ongoing clinical trial (NCT03641404) testing ergothioneine supplementation (25 mg three times weekly) in elderly individuals with mild cognitive impairment shows promising preliminary results: Significant increases in blood ergothioneine levels Improvements in global cognitive performance scores Trending improvements across multiple cognitive assessments Reduction in neurofilament light protein (a marker of neuronal injury) Recent 2025 research revealed that ergothioneine significantly increases brain-derived neurotrophic factor (BDNF) expression in nerve cells [8]

doi: 10.7554/eLife.61980 147 CosgroveJMaraisAHartmannFJBergthalerAZanoniICorradoMet al

Cell Host Microbe 29, 17571773.e10

There are rare reports of bacteria crossing gastrointestinal epithelia such as a demonstration of the pathogen H

Sleep 33(7):879887 Molina-Luna K, Pekanovic A, Rhrich S, Hertler B, Schubring-Giese M, Rioult-Pedotti M-S, Luft AR (2009) Dopamine in motor cortex is necessary for skill learning and synaptic plasticity