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This ongoing cycle has two particularly powerful outcomes: generating methyl groups (especially for cellular repair such as DNA damage) and making glutathione (the bodys most powerful antioxidant)

Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via nrf2/are/nf-Kb signal pathway

[,] An excessive formation of free radical species and oxidative stress is the primary mechanism behind neurotoxicity caused by heavy metals and demonstrated by major disturbances in the nervous system

Goodman and Gilmans The Pharmacological Basis of Therapeutics, 10th Edition, Chapter 58

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