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Amino.Acids 2009;36(2):365-372

Rats treated with ALCAR (300 mg/kg) or propionylcarnitine (300 mg/kg) after ischemia had less loss of ATP and glutathione, more intact neurons, and decreased markers of oxidative stress and energy depletion in the hippocampal CA1 region 7 days after ischemia [133]

Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency

A 2006 systematic review and meta-analysis concluded that such supplementation was associated with a 22% lower risk of cardiovascular defects in case-control studies and a 39% lower risk in cohort studies and randomized controlled trials (53)

The present study demonstrated the neuroprotective effects of Acetyl-L- carnitine (ALC) alone or in combination with caffeic acid phenethyl ester (CAPE) on lipopolysaccharide (LPS) induced neuro-inflammation, depression, and anxiety-like behavior