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Effects of l-carnitine on oxidative stress parameters in oophorectomized rats

10.1021/jp2070453

found that SIAH1, an E3 ubiquitin protein ligase, ubiquitinates HMGCR and influences cholesterol metabolism by regulating key enzymes in cholesterol synthesis, thereby reducing sensitivity to the drug cisplatin ( 4.5 Fatty acid oxidation FAO utilizes acetyl-CoA subunits generated from fatty acids to produce nicotinamide adenine dinucleotide (NADH), acetyl-CoA, and adenosine triphosphate (ATP), supporting energy production, redox homeostasis, and biosynthetic reactions

[3] Given its key metabolic roles, carnitine is concentrated in tissues like skeletal and cardiac muscle that metabolize fatty acids as an energy source

However, there were no significant differences in all-cause mortality (OR = 0.48, 95% CI: 0.21 to 1.06, P = 0.07), six-minute walk (WMD: 45.41 m, 95% CI: 14.46 to 105.29, P = 0.14), and adverse events between L-C and control groups (5.4% versus 5.8%, OR = 0.92, 95% CI: 0.44 to 1.92, P = 0.83)