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These cells were injected into the frontal lobe of nude mice to generate GBM ( n = 5 mice per group)

2010;53(7):150616 Karalius VP, Shoham DA

As a potent endogenous antioxidant, BR not only effectively scavenges superoxide and helps cells partially resist oxidative stress, but also possesses significant iron chelating ability, which effectively chelates Fe 2+ and Fe 3+ , alters the distribution of intracellular iron, and reduces the cellular uptake of iron, thus constituting an important part of the endogenous antioxidant defense system (Llido et al., 2023)

Both promote angiogenesis through different pathways, creating additive effects on blood vessel formation

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