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2011a, b) cleavage of the amyloid precursor protein (APP) that is abundantly expressed in the CNS (Aydin et al

The lack of comprehensive understanding of the underlying molecular pathology makes both the diagnosis and treatment difficult

By evading this sequestration, IGF-DES is able to engage the IGF-1 receptor (IGF-1R) more directly, making it a uniquely valuable research tool for studying IGFBP-independent IGF-1 receptor signalling

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The amount of serum ferritin is negligible but proportional to intracellular storage and can thus be a marker of iron deficiency/excess used in clinical practice to assess iron metabolism [47]