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J Biol Chem 281(42):3144031447

The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)

It may also be caused by light passing through the skull, which exerts an inhibitory effect on the pineal gland, thus leading to decreased melatonin secretion, which in turn leads to a decrease in cortisol secretion, thus enhancing the absorption of calcium by bone tissue and causing a decrease in blood calcium levels (62,63)
