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347 Activated TGF- binds to its transmembrane receptor (TR), subsequently inducing the phosphorylation of suppressor of mothers against decapentaplegic (SMAD) and its translocation into the nucleus, which suppresses hepatocyte proliferation by inhibiting the expression of downstream DNA synthesis-related genes

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Modern exposure levels are generally much lower than the concentrations that historically triggered encephalopathy or cardiopathy [22]

9 Cigarette smoke alone is sufficient to oxidize alpha-1 antitrypsin and damage DNA

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