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When joint aches do occur temporally alongside B12 therapy, they are more likely coincidental or related to other factors rather than a direct pharmacological effect of the vitamin itself

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Proinvasive properties of ovarian cancer ascites-derived membrane vesicles

Some studies suggest the orexin system is involved, and theres evidence of interactions with various neurotransmitter systems, specifically serotonergic and noradrenergic pathways
