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The title for Figure 4 should be reconsidered as the term "mutually opposite signal modulation" is unclear and/or does not reflect the description to follow. Response: We have replaced the term mutually opposite signal modulation with: amplification of MC3R signaling and attenuation of GHSR1a signaling For Figure 5, the figure legend should clarified if 5-HT2c-GHSR1a dimerization produces reduced Ca++ accumulation with (as appears to be implied by the figure) or without ligand for each receptor. Response: To make it clearer that the 5-HT2C ligand is not required, while the ghrelin ligand is, we have changed the description to read: When dimerized with 5-HT2C, GHSR1a displays a 65% reduction in ghrelin-induced Ca2+ accumulation, with this effect not requiring the presence of a 5-HT2C ligand. Reviewer #2: The review includes an excellent explanation of GSHR1a dimerization with other receptors at the cellular and molecular level and also does a good job of explaining technical aspects of this type of work

doi: 10.1016/j.ecl.2005.04.009 30 GodowskiPJLeungDWMeachamLRGalganiJPHellmissRKeretRet al

(00:37:35) Or do you wanna do all of those adjustments and everything else

Such continuity reflects how regulative regimes in public bodies often reproduce earlier statutory requirements for maintaining full accounts, to support every entry with vouchers and to undergo an independent audit, thereby reaffirming those routines in each new act

Fatty acids play a critical role in regulating macrophage polarization: saturated fatty acids (e.g., palmitic acid) promote M1 polarization [45, 46], while polyunsaturated fatty acids (e.g., DHA) and n-3 fatty acids (e.g., EPA/DHA) induce M2 polarization [45,46,47]