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USA 94 , 46814685 (1997)

Hu, and D

This process of biofilm formation is governed by bacterial communication system called quorum sensing that plays role in the synthesis, release and detection of signaling molecules (64, 65)

The key to sex dimorphism is the SRY (sex-determining region on Y) gene, whose protein product initiates the cascade of expression of genes determining the formation of testicles

That is, a genetic predisposition, an environmental injury (e.g., surgical trauma), and psychological distress can converge and synergistically drive maladaptive neuroplasticity and disrupt homeostatic systems, thereby facilitating the transition from acute nociception to a persistent chronic pain state