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However, most, if not all, of these changes are amenable to repair, either by chemical reactions or, at a later stage, by biological processes [27]

Recent population-scale genomic analysis demonstrated that protein-truncating variants in mitochondrial-related nuclear genes markedly increase the risks of hepatic fibrosis, cirrhosis, and related mortality, underscoring mitochondrial dysfunction as a causal determinant of chronic liver disease [119]

Oliver CN, Ahn BW, Moerman EJ et al (1987) Age-related changes in oxidized proteins

After two weeks of tolerance, you can increase frequency to daily use

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