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Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity

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Stem Cell Rev

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunctions in diet-induced obese mice

Glucocorticoid regulation of corticotroph POMC transcription is also indirectly mediated via other mechanisms such as down-regulation of c-jun expression and direct protein-protein mediated inhibition of CRH-induced AP-1 binding (29), inhibition of CRH receptor transcription (30), inhibition of CRH/cAMP induced activation of Tpit/Pitx1, inhibition of CRH action via the Nur response element (12), and suppression of NeuroD1 expression which in turn inhibits the positive NeuroD1/E-box interaction in the POMC promoter (31)