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The E3 ubiquitin protein ligase LINCR amplifies the TLR-mediated signals through direct degradation of MKP1

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Addressing IR is challenging because inflammation is a multifaceted, variably expressed general pathological process, and because many additional molecular mechanisms contribute to IR, the following interlocking domains: The context-dependent roles of intracellular lipid sensors, notably the peroxisome proliferator-activated receptors (PPARs), in IR development

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Acknowledgements The National Natural Science Foundation of China (82073144, J.W.), the Health Commission of Zhejiang Province (JBZX-202004, J.W.), the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (LHDMD22H310005, J.W.)