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The metabolic heterogeneity of diverse tumor types, varied clinical stages, distinct cell populations within the TME may be one of the factors contributing to the poor efficacy of metabolic-targeted drugs

Consequently, analogous with glaucoma-induced by three episcleral vein cauterizations and elevated intraocular pressure, and rapid counteraction, the brain swelling rapidly attenuated, and the intracranial hypertension (i.e., increased pressure in the ligated superior sagittal sinus) was promptly eliminated [24]

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