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Moreover, CuATSM demonstrates selective cytotoxicity towards DIPG through mechanisms intricately associated with generating H 2 O 2 and copper involvement

Edaravone (EDA), a free radical scavenger with antioxidant and anti-inflammatory properties, increases expression levels of Sirt1, Nrf2, HO-1, and GPX4 in CSDS rats, inhibiting ferroptosis and alleviating neuronal damage, which consequently improves depressive symptoms

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In contrast, more recently elucidated mechanisms such as macrophage-mediated ferroptosis or the therapeutic potential of sophisticated nano-therapies, while compelling in rodent models, remain primarily hypothesis-generating in the specific context of human SRMI and await validation in clinical cohorts (49, 119)
