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10.1093/gerona/glaa248 40 GongJ.ZhaoH.LiuT.LiL.ChengE.ZhiS.et al (2019)

The deletion of Bhmt gene in mice resulted in an appreciable reduction in SAM/SAH ratio (i.e., the methylation potential) and a several-fold increase in hepatic and plasma total homocysteine (tHcy) concentrations (Teng et al., 2011)

Abstract Valproic acid (VPA) is a broad-spectrum antiepileptic drug and is usually well tolerated, but rare serious complications may occur in some patients receiving VPA chronically, including haemorrhagic pancreatitis, bone marrow suppression, VPA-induced hepatotoxicity (VHT) and VPA-induced hyperammonaemic encephalopathy (VHE)

coronary artery disease

The TMAO-generating enzyme FMO3 reduced RCT, decreased the intestinal absorption of cholesterol, and changed the composition and size of the bile acid pool (Warrier et al., 2015