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Description
Since the OH group on Tyr is the phosphorylation target catalyzed by receptor tyrosine kinases (RTKs), having the steric hinderance of NO 2 on the 3-position of Tyr greatly hinders the effective phosphorylation of the 4-OH group on Tyr

Int J Mol Sci 18: 2504, 2017
An aggressive and drug-resistant form of breast cancer, known as FOXM1 overexpression, is associated with a dismal prognosis

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