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The extreme changes in microRNAs and alterations in the epigenetic landscape indicate that DMSO is not inert
This parental line, which intrinsically expresses minimal CFTR protein, serves as a reliable model and is frequently used as a null-background for the stable overexpression of wild-type, F508del, or other CFTR variants, enabling the study of their function and response to modulators (Ousingsawat et al., 2011
doi: 10.1155/2017/5784759
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Support Care Cancer 20:625632
