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The liver receives 75% of its blood supply from the portal vein, which carries blood returning to the heart from the small intestine, stomach, pancreas, and spleen

For this reason, when a patient ingests a controlled substance, either legitimately or illegally, glucuronide conjugates, such as Morphine-6-glucuronide will be present in the subjects blood as well as urine

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HDAC3 promotes Sertoli cell maturation and maintains the blood-testis barrier dynamics