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Sci Rep 6 , 19245 (2016)

Treatment duration typically follows 6-12 week cycles with 4-8 week breaks, though no evidence supports this pattern

Antioxidants that act by scavenging lipid free radicalsincluding liproxstatin-1, ferrostatin-1, and -tocopherol (vitamin E)have been shown to significantly inhibit ferroptosis [118120]

The ensuing neuroinflammation can emerge as long-term cognitive impairment and neurodegeneration (Haruwaka et al., 2019)

This intracellular alteration may downregulate Gpx4 expression, resulting in increased lipid peroxidation, a shift in cellular redox balance toward oxidative conjugation, and induction of ferroptosis