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This targeted uptake in diseased tissue is a genuinely unusual pharmacological property that makes KPV particularly well-suited to inflammation-driven gut conditions like ulcerative colitis and IBD

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A water molecule in the close vicinity of Gln390 hydrogen bonded to the hydroxyl group of Ser388 and -amino group of Gly484 has been reported to enhance nucleophilicity of OG atom of Thr391 that appears crucial in autoprocessing (Figure 2

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