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In recent years, the effects of GLP-1 agonists/analogues on the CNS have gained relevance due to emerging evidence supporting the neuroprotective effects of these molecules

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[14] In severe or inherited forms of biotin deficiency (such as biotinidase deficiency), even higher daily doses may be employed, and lifelong supplementation can be necessary under medical guidance

PSC is commonly associated with inflammatory bowel disease and increased risk of cholangiocarcinoma, gall bladder cancer, colorectal cancer, and hepatocellular carcinoma