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The BBTB is created by brain tumor capillaries located between tumor cells and is composed of specialized endothelial cells within the tumor vasculature[58]

Recent studies have also demonstrated a difference in the intestinal permeability between individuals with or without T2D, which implicated a crucial contribution of intestinal permeability to metabolic disorders 103

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N Engl J Med 371:313325 Gough SC, Bode B, Woo V et al (2014) Efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone: results of a phase 3, open-label, randomised, 26-week, treat-to-target trial in insulin-naive patients with type 2 diabetes

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