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"Valproic Acid-Induced Liver Injury: A Case-Control Study from a Prospective Pharmacovigilance Program in a Tertiary Hospital"

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The loss-of-function mutant of ANGPTL8 is associated with reduced TG and LDL-C levels and increased HDL-C levels compared with the ANGPTL3 loss-of-function mutant, but because this mutant is rare, there is insufficient evidence to assess its cardiovascular protective effects (203,210)

A central hallmark of atherosclerosis is foam cell formation characterized by uncontrolled lipoprotein accumulation within macrophages (Figure 2)

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