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Simultaneously, MPs/NPs impair lysosomal degradation pathways, exacerbating intraneuronal -synuclein accumulation and promoting the formation of Lewy bodies

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Doxorubicin induces endotheliotoxicity and mitochondrial dysfunction via ros/enos/no pathway

In Parkinsons disease (PD), astrocytic mitochondrial dysfunction disrupts the clearance of -synuclein through the ubiquitin - proteasome system and autophagy pathways, promoting the formation of Lewy bodies

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