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Oxygen and glucose deprivation lead to the stabilization and/or upregulation of microglial HIF-1 (Xu et al., 2023), which, in turn, results in increased autophagy, TLR4, IL-1, and IL-18 expression, and NLR family pyrin domain containing 3 (NLRP3) inflammasome formation, suggesting HIF-1 contributes to the proinflammatory phenotype of microglia after a stroke event (Guo et al., 2009

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The high acetaldehyde concentrations described share similarity to symptoms of the flush (flushing of the skin, accelerated heart rate, shortness of breath, throbbing headache, mental confusion and blurred vision)

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