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Joint pain is an extremely prevalent symptom in the general population, affecting millions of people in the UK due to osteoarthritis, inflammatory arthritis, fibromyalgia, and other conditions

Furthermore, it reduces the mass of ASM, epithelial collagen deposition, and goblet cell hyperplasia [362,368], all of which are increased in vitamin D deficiency [304]

This might lead to an up-regulation of SREBP2 and a subsequent increase in UCP2

Research on the MOTS-c analog CB4211 used 25 mg per day (a much higher dose), but native MOTS-c protocols trend lower

Of course any side effects need continued scrutiny since no one has said how long that might last