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It seems that the antagonistic pleiotropy of insulin/IGF-1 signaling has profound effects on both the healthspan and lifespan of mammalian species

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Moreover, ribosomal dysfunction impairs the synthesis of anti-apoptotic proteins and mitochondrial respiratory chain proteins in cardiomyocytes, exacerbating post-ischemic cardiomyocyte apoptosis [71], while abnormal ribosomal pathways in macrophages alter the translation efficiency of pro-inflammatory and anti-inflammatory cytokines to regulate the inflammatory microenvironment in infarcted areas [72], and altered expression of ribosome-related genes is closely correlated with AMI-related prognostic indicators such as infarct size and cardiac function recovery [73]

doi: 10.1016/j.jnutbio.2013.11.002

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