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Another possible explanation was that there was a conformational change of DPPC liposomes at 34.9 C

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Effect of non-pharmacological interventions on cognitive function in multiple sclerosis patients: a systematic review and network meta-analysis

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There are several main goals of preclinical safety testing: i) identification of organ toxicity, ii) the relationship to drug exposure, iii) determination of ontarget and offtarget effects, iv) potential relevance to humans, and v) identification/qualification of safety biomarkers to monitor in the clinic