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Preclinical Safety: What the Animal Data Actually Shows Across preclinical work, BPC-157 looks remarkably benign from a classic toxicology standpoint

The deficiency of neurotrophic support leads to neuronal atrophy, impaired axonal transport, and decreased nerve regeneration capacity

Interestingly, TRX itself is a target gene of NFB upon stimulation of ROS, lipopolysaccharide (LPS), phorbol ester PMA and inflammatory cytokine TNF and IL-1 (357), presumably preventing over-expression of potentially deleterious gene products

The heteroplasmic female mice were backcrossed for 20 generations with C57BL6/J2 mice originally obtained from the Jackson Laboratory, and all subsequent females were mated with males from the same C57BL/6 J line maintained by brother/sister mating