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Causes of high vitamin B12 The causes fall into two broad categories: exogenous (something youre taking in) and endogenous (something happening inside your body)

When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established

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Injection site reactions : The most common side effects are mild and short-lived, including soreness, redness, or slight swelling at the injection site