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While systemic administration of therapeutics has been commonly used to treat CNS (Central Nervous System) disorders, this approach faces notable hurdles that diminish the success of many neural treatments (9)

10.1016/j.scitotenv.2023.162280 2 AlyoshinaN

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Spermidine-mediated induction of autophagy requires that the pro-autophagic transcription factor identified as TFEB (transcription factor EB, where the EB refers to enhancer box binding site) be activated