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However, it could be just that there is a cellular- and temporal-specific regulation of the aggregation process in which the appearance of the visible inclusions of mutant ATXN3 precedes toxicity and neuronal death in some cells, whereas in others, the bigger aggregates are never formed as toxicity surpasses aggregation

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Furthermore, as discussed, the potential contributions of collateral sprouting from the saphenous nerve and/or intraspinal sprouting to the reorganization of afferent terminal fields should be further assessed

Gibb, M