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There is no single pharmacological treatment for MetS, and patients with polypharmacy, limited adherence to current pharmacotherapy, and associated comorbidities find it challenging to continue taking multiple medications

As bile is made of 90% water, cholesterol which is totally insoluble in aqueous solutions must be properly solubilized

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For example, DNA strand breaks and reversible cross-links with DNA or histone proteins of nucleosome core particles from AP sites affect transcription and replication in cells, further inducing gene mutations, which may cause apoptosis or cell carcinogenesis [19, 20]

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