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Aging (Albany NY), 14:4247-4269

High-dose oral b12 protocols Oral b12 can overcome absorption issues through mass action

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The data is striking: in a Phase 2 trial published in the New England Journal of Medicine, the highest doses produced an average ~24% body-weight reduction at 11 months more than any currently approved weight-loss drug (American Diabetes Association)

CDO1 is a nonheme iron metalloenzyme, transforming cysteine to taurine by catalyzing the oxidation of cysteine to its sulfinic acid, which prevents cytotoxicity from elevated cysteine levels (Stipanuk et al., 2009)
