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Regardless, patients with TDP-43 mutations have TDP-43 pathology, and the mouse model that have A315T mutation has TDP-43 accumulations mostly in the nucleus, have extensive ubiquitinated protein accumulations in the cytoplasm, and based on the antibody used, pTDP-43 are also detected in the cytoplasm 19,46

In research settings, 5-Amino-1MQ does not show affinity for adrenergic receptors or increase heart rate/blood pressure in the way that compounds like caffeine, ephedrine, or clenbuterol do
In the case of GSAO, a reversible renal toxicity described in preclinical studies at the maximal tolerated dose was not observed in human during clinical Phase I (Tsimberidou et al., 2009

Ghandadi and Sahebkar, 2017

doi: 10.3390/ijms221910890 124 PoinasAPerrotPLorantJNerrireONguyenJMSaiaghSet al