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Consistently, a recent study found that GCN2 activation by dabrafenib, an anticancer reagent, blocks the generation of myeloid-derived suppressor cells (MDSCs) in murine melanoma, indicating that systemic activation of GCN2 may enhance anti-tumor immunity (138)

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Nevertheless, more diverse vaginal microbiomes have been observed globally across different healthy populations (North America 146 , Scandinavia 147 , South Africa 148 , and Kenya 149 ), but are usually associated with adverse sexual and reproductive outcomes 150