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doi: 10.1210/jc.2014-3014 43 Sanchez-BilbaoLMartinez-LopezDRevengaMLopez-VazquezAValls-PascualEAtienza-MateoBet al

Leptin, also a hormone, targets receptors in the arcuate nucleus of the hypothalamus to regulate appetite and to achieve energy homeostasis

The resulting GABA then potentially affects the brain via the vagus nerve via the gut-brain axis or by increasing GABA levels in the blood

Urine organic acids were abnormal in the majority in which it was tested with elevations in TCAC metabolites, specifically elevations in citrate and/or isocitrate representing the majority of the abnormalities

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