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In addition, lipophilicity, molecular weight and surface charge of intranasal drugs also affect the delivery efficiency

10.1155/2018/6434910 153 YodaK.MiyazawaK.HosodaM.HiramatsuM.YanF.HeF

Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N -hexanoic-Tyr-Ile-(6) aminohexanoic amide (dihexa), a potent cognitive-enhancing molecule that proved to be very stable, capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, slowly cleared from the blood compartment, and sufficiently BBB-permeable

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Schwann cell type V collagen inhibits axonal outgrowth and promotes schwann cell migration via distinct adhesive activities of the collagen and noncollagen domains