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As we get older, however, NAD+ production slows down, leading to mental and physical fatigue

This self-amplifying mechanism mediated by autocrine signaling can lead to aberrant pain behaviors through the continuous production of pro-inflammatory cytokines, predominantly TNF- ( In the spinal dorsal horn (SDH) of rats with IC, upregulation of Iba1 (a marker of microglial activation), GFAP (glial fibrillary acidic protein, a marker of astrocyte activation), p-p38 (a MAPK), p-JNK, IL-1, and TNF- has been observed

L., Adams, S

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Name, J